DMPK Studies

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Preclinical (DMPK) studies

In Vitro ADME

Aqueous solubility and stability of the compounds at different pH, Stability of the compounds at ambient temperature, 2-8/-20°C
Short term and long term stability of the compound in biological matrices(plasma/serum) Metabolic stability studies using cellular (hepatocytes from rat, mouse, human etc) and sub cellular fractions, metabolic stability studies recombinant CYP isoforms such as CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2
Cell permeability assays – PAMPA, MDCK, and CaCo-2
Plasma/serum protein binding by ultrafiltration / equilibrium dialysis technique
In-Vivo DMPK services

Pre-formulation development
Absolute Bioavailability studies
Single, Multiple and cassette dosing
Ascending dose PK in rodents
PK studies in cannulated and non-cannulated rodents
In vivo models

Inflammatory pain: CFA, Carrageenan, Capsaicin, Formalin models, collagen-induced arthritis
IBD: DSS induced colitis in mice, TNBS induced colitis in rats
Respiratory: Rodent models of LPS-induced neutrophilia and ovalbumin induced eosinophilia
Cytokine Release Models: Mouse models of LPS induced TNF α and IL-1 release, rat model of ATP activated IL-1β release
Acute and Chronic OGTT, IPGTT models (glucose & insulin)
DIO mouse model (pair fed studies)
Acute model for GLP-1 induced Incretin secretion & endocrine secretion (PYY / CCK)
Acute model for Malonyl CoA lowering