Infectious diseases & Virology

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In vitro and In vivo Assessment of Immunomodulatory studies against Zika Virus, Influenza A, & HCoV-229E

Virology

  • In vitro and In vivo Assessment of Immunomodulatory studies against Zika Virus, Influenza A, & HCoV-229E
  • Cytokine levels –IgG, IgM, IL-6, IFN-γ, and TNF-α, IL-2, IL-12, IL-10
  • Immuno-phenotyping of cells by flowcytometry –T cells, B cells, NK cells
  • Haematological, biochemical and Histopathology of organs
  • In-vitro neutralization assay
  • In-vitro immunogenicity using PBMCs
  • Cytotoxic evaluation of novel anti-viral peptide in VERO cells
  • Plaque Reduction Assay
  • In vivo efficacy of novel anti-viral
  • Effect of novel anti-viral peptide in preventing the viral protein synthesis
  • Cytopathic effect for antiviral compounds/ Formulation
  • Relative expression/ identification by using RTPCR method
  • Screening of antiviral compounds/Vaccines both in cell lines & animal models