Skanda Life Sciences offers cutting-edge pre-clinical services to support respiratory disease research and drug discovery
Respiratory
Skanda Life Sciences offers cutting-edge pre-clinical services to support respiratory disease research and drug discovery. Our pulmonary cell cultures and in vitro assays provide valuable insights into respiratory diseases, drug-induced lung injury, and the effects of drugs on lung function. Leveraging state-of-the-art technologies, we facilitate the development of novel therapeutics for respiratory disorders, striving to improve patient outcomes and quality of life.
In Vitro Screening Assays:
Cytotoxicity Assays
Measure cell viability and cytotoxicity in response to various stimuli, such as pollutants, toxins, or potential therapeutic agents.
Inflammation Assays
Evaluate the inflammatory response of lung cells to different stimuli, including allergens, pathogens, or inflammatory mediators.
Barrier Function Assays
Assess the integrity and permeability of the lung epithelial barrier, which plays a critical role in preventing the entry of harmful substances into the lungs.
Oxidative Stress Assays
Measure the levels of reactive oxygen species (ROS) generated by lung cells and assess the cellular response to oxidative stress.
Functional assays using cell lines expressing specific receptor subtypes
Assays targeting adrenergic and cholinergic receptors encompass cAMP accumulation, calcium mobilization, ligand binding, reporter gene expression, receptor internalization, desensitization.
Mucin Production Assays
Quantify the secretion of mucins by respiratory epithelial cells, relevant for studying mucus hypersecretion in respiratory diseases.
