Toxicology

Acute Toxicity studies, Sub-chronic & Chronic Toxicity

Based on OECD guidelines/ customized protocols

• Acute oral/dermal and Inhalation toxicity study
• Eye irritation study
• MTD studies in rodents and non-rodents
• Skin and eye irritation study
• Skin sensitization study

Chronic

• 28/90/180 Days Repeated Dose Toxicity
• Carcinogenicity /chronic Toxicity Studies/ Combined Chronic/ Neurotoxicity Studies
• Juvenile Toxicity
• DRF in rodents and non-rodents

Genetic Toxicity Studies

• Reverse Mutation Assay (Ames Assay)
  Ames test – Using 2 or 5 strains of Salmonella Typhimurium
• Micronucleus Test (MNT)
  In-Vivo Mammalian Erythrocyte Micronucleus Test in Mice
• Chromosomal Aberration Assay
  In-Vitro Mammalian Chromosome Aberration Test
• Skin irritation test & Cytotoxicity study
• Sensitization Assay

Alternative to animal study

• In Vitro Ocular Irritation Test (EpiOcularTM)
• In Vitro 3T3 NRU Phototoxicity
• Dermal absorption study, Photo toxicity and Irritation study
• Isolated tissue studies & Chicken Eye Test
• In Vitro Ocular Irritation Test (EpiOcularTM)
• In Vitro Skin Irritation Test (EpiskinTM/EpidermTM)
• In Vitro Dermal absorption (EpiskinTM/EpidermTM) / Human Cadaver Skin/Porcine skin/Cornea
• Local Lymph Node Assay (LLNA): BrdU-ELISA
• Direct Peptide Reactivity Assay (DPRA)

Pathology Services

We provide independent pathology services, which includes –

• Necropsy and Gross Pathology
• Histopathology slide preparation and evaluation
• Hematoxylin and Eosin (H & E) Staining and Special Staining’s (as per requirement)
• Immunohistochemistry, Hematology, Clinical Chemistry
• Clinical Pathology & Urinalysis