Global Calcium is one of the leading manufacturers and exporters of Potassium Chloride CAS no. 7447-40-7, Mineral Actives . We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.

As manufacturer of Potassium Chloride we hereby state the following facts about the drug:

Potassium Chloride is a metal halide composed of potassium and chloride.  Potassium maintains intracellular tonicity, is required for nerve conduction, cardiac, skeletal, and smooth muscle contraction, production of energy, the synthesis of nucleic acids, maintenance of blood pressure, and normal renal function. This agent has potential antihypertensive effects and when taken as a nutritional supplement may prevent hypokalemia. Potassium chloride appears as white colorless cubic crystals. Strong saline taste. It also has a role as a fertilizer.

Pharmacology:

The potassium ion is in the principal intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal, and smooth muscle, and the maintenance of normal renal function. An active ion transport system maintains this gradient across the plasma membrane. Potassium is a normal dietary constituent and under steady-state conditions, the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine. Potassium depletion will occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate of potassium intake. Such depletion usually develops as a consequence of therapy with diuretics, primary or secondary hyperaldosteronism, diabetic ketoacidosis, or inadequate replacement of potassium in patients on prolonged parenteral nutrition. Depletion can develop rapidly with severe diarrhea, especially if associated with vomiting. Potassium depletion due to these causes is usually accompanied by concomitant loss of chloride and is manifested by hypokalemia and metabolic alkalosis. Potassium depletion may produce weakness, fatigue, disturbances of cardiac rhythm (primarily ectopic beats), prominent U-waves in the electrocardiogram, and, in advanced cases, flaccid paralysis and/or impaired ability to concentrate urine.

Supplemental potassium in the form of high potassium food or potassium chloride may be able to restore normal potassium levels.

Indication:

• For use as an electrolyte replenisher and in the treatment of hypokalemia
• Parenteral nutrition
• Potassium is involved in numerous enzymatic reactions, in nerve conduction, muscle contraction, and carbohydrate metabolism.

Other related information:

• The reported mutagenic effect of potassium chloride most probably results from a disruption of the osmotic balance of cells with subsequent interference with chromosomal stability. This may result in the clastogenic effects (DNA breakage and chromosome structural instability) due to K+ effects on sequestering of Mg2+ ions required for normal maintenance of chromatin integrity. Other chemicals may also exert such effects (e.g. NaCl, sucrose).
• Potassium and chloride are also important in the regulation of the acid-base balance of the body. Potassium is the principal base in tissues of blood cells, and Cl maintains electrochemical neutrality by anion exchange with bicarbonate (the chloride shift) in the CO2 transport in the blood-red cells.

Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market