Global Calcium is one of the leading manufacturers and exporters of Ferric Pyrophosphate CAS no. 10058-44-3, Mineral Actives . We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.

As manufacturer of Ferric Pyrophosphate we hereby state the following facts about the drug:

Ferric pyrophosphate is an iron replacement product intended for the treatment of iron loss or iron deficiency in patients with chronic kidney disease and pregnant ladies. This molecule has a milder gastrointestinal effect compared to other forms of iron supplements

Free iron presents several side effects as it can catalyze the free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate¹ having milder gastrointestinal tract effects and present higher bioavailability.

The usage of ferric pyrophosphate is based on the strong complex formation between the two species. Besides, the capacity of pyrophosphate to trigger iron removal from transferrin, enhance iron transfer from transferrin to ferritin and promote iron exchange between transferrin molecules. These properties make it a very suitable compound for parenteral administration, iron delivery into circulation, and incorporation into hemoglobin.

Solubility & Appearance:

The Increase in solubility for ferric pyrophosphate is attributed to the formation of soluble complexes between Fe (III) and pyrophosphate ions.

The 10 fold increase in the concentration of ionic iron at pH 7 – 8.5, which is close to the pH of the small intestine is expected to be beneficial for enhancing iron bioavailability.

Ferric pyrophosphate is a widely used iron source in food fortification and in nutritional supplements, due to its white color, which is very uncommon for Fe salts.

Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market