Global Calcium is one of the leading manufacturers and exporters of Atracurium Besylate CAS no. 64228-81-5, API, (Active Pharmaceutical Ingredient). We support the customers with exhaustive documentation. As a USDMF & EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979.

As manufacturer of Atracurium Besylate we hereby state the following facts about the drug:

Atracurium besylate is a synthetic di benzenesulfonate derivative muscle relaxant. Atracurium besylate acts as a non-depolarizing neuromuscular blocking agent, with short to the intermediary duration of action and no significant cardiovascular effects. Not dependent on kidney function for elimination, it provides clinical advantages over other non-depolarizing, neuromuscular blocking agents. Atracurium besylate is the bisbenzenesulfonate salt of atracurium. It also has a role as a nicotinic antagonist and a muscle relaxant.

Drug Indication:

• Atracurium besylate is used as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
• A non-depolarizing neuromuscular blocking agent with a short duration of action. Its lack of significant cardiovascular effects and its lack of dependence on good kidney function for elimination provide a clinical advantage over alternate non-depolarizing neuromuscular blocking agents.

Mechanism of action:

Atracurium antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.

Global Calcium is a leading manufacturer of this drug. We manufacture this pharmaceutical drug and make it available to domestic and overseas market