In Vitro ADME

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Aqueous solubility and stability of the compounds at different pH, Stability of the compounds at ambient temperature, 2-8/-20°C

In vitro ADME

  • Aqueous solubility and stability of the compounds at different pH, Stability of the compounds at ambient temperature, 2-8/-20°C
  • Short term and long-term stability of the compound in biological matrices(plasma/serum) Metabolic stability studies using cellular (hepatocytes from rat, mouse, human etc) and sub cellular fractions, metabolic stability studies recombinant CYP isoforms such as CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2
  • Cell permeability assays – PAMPA, MDCK, and CaCo-2
  • Plasma/serum protein binding by ultrafiltration / equilibrium dialysis technique