Skanda offers preclinical development and offer drug development services from Hit to lead generation of drug substance and drug product.
Chemistry Capabilities
SKANDA Medicinal Chemistry Teams Offer the Following Services:
Synthetic Chemistry
Skanda offers a vast range of synthetic chemistry services through an experienced team of scientists equipped with the latest technology and infrastructure. Our Scientists devise the most effective route for the synthesis of novel/complex compounds, having delivered value-added results for various drug discovery projects. Our focus is on delivering, cost-effective, and timely solutions to meet the needs of clients.
Capabilities
Skanda life Sciences offers research services from target validation to pre-clinical candidate selection under one roof across the multiple therapeutic areas.
We bring a deep knowledge of asymmetric transformation methods and organometallic chemistry to accelerate the discovery of active compounds for drugs. Our scientists have diverse synthetic experience ranging across building blocks, reference compounds, scaffold analogues, impurities, prodrugs (mg to kg scale), focused library, & metabolite synthesis, heterocyclic chemistry, stereoselective synthesis, natural product synthesis, route scouting and early process.
Medicinal Chemistry
Development
Skanda offers preclinical development and offer drug development services from Hit to lead generation of drug substance and drug product.
Discovery chemistry
With robust experience, Skanda provides integrated discovery chemistry services, including medicinal chemistry, synthetic, NCE, PROTAC, and Peptides based allowing discovering active drug candidates.
Our discovery chemistry services effectively use AI & cheminformatics for multipara metric optimization, and are backed by strong analytical chemistry support, as well as efficient data and compound management.
Flexible Delivery Model for Chemistry Services
A flexible discovery model enables clients to work closely with our chemistry teams.
Depending on requirements, clients can either choose a FTE (full-time-equivalent) or a FFS (fee-for-service) pricing model for discovery chemistry services.
Clients can access our medicinal chemistry services with an emphasis on chemistry capabilities such as synthesis (includes library design and computational chemistry). Alternatively, we also provide comprehensive services that are inclusive of ADME-PK, Efficacy, and biological support (functional based assays, cell-based assays, oncology, immune-oncology).
Advancing drug discovery by applying the right medicinal chemistry approaches to deliver high-quality drug candidates
Skanda Life Sciences pool of experienced and multi-disciplinary scientists collaborate to efficiently assess hits, optimize compounds, and deliver high quality candidates in the hit-to-lead and lead optimization.
In additional, our scientists are experts in computational chemistry, in vitro and in vivo biology, drug metabolism and pharmacokinetics, as well as toxicology, and are supported by advanced research instrumentation.
The team has a strong track record of having successfully delivered numerous preclinical candidates in collaboration with various clients. Our experience includes therapeutic areas such as oncology, AD, CNS, metabolic disorder, pain & inflammation, antiviral, antibacterial and autoimmune disorders among others.
ong others.
Hit-To-Lead
Drawing on vast scientific experience, our team optimizes hits and identifies the most promising active compounds to progress to the lead optimization stage. Our capabilities include:
- High-throughput synthesis
- Evaluation of hits for drug, potency and selectivity
- Conventional and computational chemistry driven design of novel analogs with early absorption, distribution, metabolism, and excretion properties
- In vitro and in vivo screening of compounds for optimization
- Route scouting and focused library synthesis compounds
Lead Optimization
Identified lead compound from the hit-to-lead stage, our scientists work on optimizing and evaluating the leads through various screening studies until a suitable candidate is ready. Our lead optimization capabilities include:
- Design of hypothesis to optimize hits for desired efficacy and potency
- Optimization studies for potency, selectivity, in vivo efficacy, pharmacokinetic/pharmacodynamic modelling (PK/PD) profile, safety and toxicity profile
- Early scale-up of molecules to support in vivo efficacy and toxicity studies
- Multi-parameter optimization of leads
- Selection of preclinical candidates
Computational Chemistry
Computational Chemistry and Molecular Modelling to fast track Drug Discovery Programs
Services in computational chemistry and molecular modelling from hit identification to lead optimization and hit-to-lead transition are offered by Anax Laboratories.
Using cutting-edge computer simulations and modelling tools, our computational scientists collaborate with internal medical chemists to deliver high-various quality hits and optimized leads in the drug discovery design process.
Delivering numerous clinical candidates across a range of therapeutic areas has been made possible in large part by the Computer Aided Drug Discovery (CADD) team.
Capabilities
- Docking and homology modelling based on structure;
- Conformational analysis and comparisons based on QM/MM;
- Methodical homology modelling
- Target-based focused library listing;
- Access to extensive commercial computational chemistry software (Schrödinger suite, Gaussian, Spartan 18);
- Multiple GPU workstations with 64-core processors and terminal stations;
- Implicit binding energy calculation;
- Pharmacophore and shape-based virtual screening;
- Fragment-based virtual screening and fragment expansion;
- Combinatorial library generation and customized filtration;
Approaches we adapt in drug designing
- Computer-aided drug design (CADD),
- Fragment-based design (FBDD),
- Structure-based design (SBDD),
- Analog-based design (ABDD),
- Library design (LBDD),and approaches based on chemo informatics
Analytical Chemistry Capabilities
Skanda provides complete array of analytical services, to support the drug development, process research
- Method development and validation using HPLC, LCMS and GCMS
- Structure elucidation by NMR
- Impurity profiling
- Organic Volatile Impurities and Residual Solvents
Services
- Method development and validation for different pharmaceutical products and new chemical entities using HPLC with variable detectors.
- Molecular ion determination and fragmentation using LC-MS/MS.
- Determining the structure for a given compound by recording NMR spectra like 13C-NMR, 1H-NMR and other 2D-NMR.
- We are committed to provide quality services.
Infrastructure
- Equipped with all instruments – LCMS/MS 4000 AB Sciex (Triple quad & qTrap), Shimadzu & Agilent HPLC, GC, GCMS, Flash chromatography, Prep-HPLC – qualified, sophisticated and calibrated
- Complete analytical services can provide for support in drug development and process research
- Our immense experience ensures to provide rapid and reliable data
