In vitro Permeability

  • PAMPA
  • Caco-2
  • MDCK (wild type)

Animal Pharmacokinetics

Pharmacokinetics by routes viz., oral, intravenous, intraperitoneal, subcutaneous in mice rats etc

  • Tissue Distribution
  • Brain to Plasma Ratio
  • Biliary Excretion
  • Mass Balance

Physicochemical properties

  • Solubility (Thermodynamic and Kinetic method)
  • Log D (Octanol/water and Cyclohexane/water)
  • Chemical Stability
  • Blood Partitioning